The cell cycle and cytoskeletal morphogenesis in Trypanosoma brucei.

نویسندگان

  • K Gull
  • C Birkett
  • R Gerke-Bonet
  • A Parma
  • D Robinson
  • T Sherwin
  • R Woodward
چکیده

I . Hayes, J. I). & Wolf. C. R. ( IYSX) in Ghituthione (’onjugation (Sies, H. & Ketterer. 8.. eds), pp. 315-355. Academic Press Limited, London 2. Meister. A. ( 1980) in Ghrtrithione: Chemicul, Biochemical, mid Medical Aspc~rts (Dolphin, D.. Poulson. R. & Avramovic, 0.. A), pp. 307-474, John Wiley & Sons. New York 3. Kramer, R. A,, Zakher, J. & Kim, G. (1988) Science 241, 604-696 -1. Riirlamh. A. H.. Hlackburn. P.. Ulrich, P.. Chait. B. T. & Cerami.A.( I9XS).Scienc~227, 14x5-14x7 5. Fairlamb, A. H., Henderson, G. B. & Cerami, A. ( I 986) Mol. Hio(.hem. I’nrusitol. 2 1, 247-257 6. Tabor, H. & Tabor. C. W. ( 1975) J. lliol. C‘hem. 250. 2048-2654 7. Fairlamb, A. H. & Cerami, A. ( 1 98s) Mol. Hiocher. I’urusitol. 14. 1x7-198 8. Shames. S. L.. Fairlamb. A. H.. Cerami, A. & Walsh, C. T. ( 1986) Bioc.hemistry25, 3519-3526 9. Jockers-Scherubl. M. C.. Schirmer, R. H. & Krauth-Siegel, R. L. (1089) Eur. J. Riochem. 180. 267-272 10. Penketh, P. G. & Klein, R. A. (19x6) Mol. Hiochem. I’urusitol. 20, I 11-121 I I . Penketh, P. G.. Kennedy, W. P. K., Patton, C. L. & Sartorelli, A. C . ( 1087) FEB.SI.~~tt. 221.427-431 12. Henderson, G. B., Fairlamb, A. H. & Cerami. A. (1987) Mol. Hiochem. I’trrusitol. 24, 39-45 13. Boveris, A,, Sies, H.. Martino, E. E., Docampo, R., Turrens, J. F. & Stoppani, A. 0. ( 1980) Hioc.hem. J. 188,643-648 14. Yawetz; A. & Agosin. M. ( I98 1 ) C’omp. Biochem. I’hyiol. 68B. 237-243 IS. Shim, H. & Fairlamb, A. H. (1988) J. Gen. Microhiol. 134, 807-8 17 16. Fairlamb, A. H. (1988) in I’olynrnines in Biochemical trnd C’linic~crl Hiwurch: Novel Hiochcmicul. I’hysiologicul mi l ( ‘linicd Asprcts (Arlvunces in Expivimentril hlidicine tirid Biolohy, id. 250) (zappia. v. & Pegg, A. E., eds). pp. 667-674, Pienum Press, New York 17. Phillips, M. A,, Coffino, P. & Wang. C. C. ( 1987) J. Hiol. Chem.

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منابع مشابه

Giant FAZ10 is required for flagellum attachment zone stabilization and furrow positioning in Trypanosoma brucei

The flagellum and flagellum attachment zone (FAZ) are important cytoskeletal structures in trypanosomatids, being required for motility, cell division and cell morphogenesis. Trypanosomatid cytoskeletons contain abundant high molecular mass proteins (HMMPs), but many of their biological functions are still unclear. Here, we report the characterization of the giant FAZ protein, FAZ10, in Trypano...

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Trypanosomes use a microtubule-focused mechanism for cell morphogenesis and cytokinesis. We used scanning electron and video microscopy of living cells to provide the first detailed description of cell morphogenesis and cytokinesis in the early-branching eukaryote Trypanosoma brucei. We outline four distinct stages of cytokinesis and show that an asymmetric division fold bisects the two daughte...

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Proteomic identification of novel cytoskeletal proteins associated with TbPLK, an essential regulator of cell morphogenesis in Trypanosoma brucei

Trypanosoma brucei is the causative agent of African sleeping sickness, a devastating disease endemic to sub-Saharan Africa with few effective treatment options. The parasite is highly polarized, including a single flagellum that is nucleated at the posterior of the cell and adhered along the cell surface. These features are essential and must be transmitted to the daughter cells during divisio...

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An orphan kinesin in trypanosomes cooperates with a kinetoplastid-specific kinesin to maintain cell morphology by regulating subpellicular microtubules.

Microtubules are a vital part of the cytoskeleton of eukaryotic cells and are involved in various cellular processes. The cytoskeleton of Trypanosoma brucei is characterized by an array of subpellicular microtubules and is essential for maintenance of cell shape and polarity, but little is known about the regulation of the assembly and organization of the subpellicular microtubule corset. Here,...

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A coiled-coil- and C2-domain-containing protein is required for FAZ assembly and cell morphology in Trypanosoma brucei.

Trypanosoma brucei, a flagellated protozoan parasite causing human sleeping sickness, relies on a subpellicular microtubule array for maintenance of cell morphology. The flagellum is attached to the cell body through a poorly understood flagellum attachment zone (FAZ), and regulates cell morphogenesis using an unknown mechanism. Here we identified a new FAZ component, CC2D, which contains coile...

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Efficacy of repeated doses of diminazene aceturate (Dinazene®) in the treatment of experimental Trypanosoma brucei infection of Albino rats

The efficacy of repeated doses of Dinazene® in Albino rats experimentally infected with Trypanosoma brucei (Gboko strain) was investigated. A total of 30 adult female Albino rats weighing 130-190 g were used for the study. They were assigned to six groups (groups A-F) of five rats each. Groups A-D were infected intraperitoneally with 1.0 × 106 trypanosomes in 400 μL of PBS diluted blood while g...

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عنوان ژورنال:
  • Biochemical Society transactions

دوره 18 5  شماره 

صفحات  -

تاریخ انتشار 1990